I can't believe I'm picking so many road to teams to win in Week One. But that's just the way it seems to be working out. The first week is always a little of an adventure, so here it goes.
Green Bay 27 @ Chicago 21: Can Jay Cutler regain some prior form and challenge the Packers? I doubt it.
Kansas City 24 @ Houston 21: The Texans expect to be improved and hope to challenge the Colts in the AFC North. The Chiefs aren't a great road team, but if they look to unseat Denver in the AFC West, they'll need to win games like this.
Cleveland 17 @ New York Jets 20: The Browns are still trying to figure things out at QB. New Jets coach Todd Bowles will continue Rex Ryan's defensive focus.
Indianapolis 30 @ Buffalo 23: There's a lot of buzz in Buffalo, with Tryod Taylor moving from the backup at Baltimore to start for the Bills. Rex Ryan can make some noise with an upset of the team many are picking for the Super Bowl.
Miami 28 @ Washington 20: As a Washington fan, I would love for the beleaguered Redskins to find a way to defeat a vastly improving Dolphins team. But even with Kirk Cousins behind center, I don't see it happening.
Carolina 31 @ Jacksonville 20: Twenty years ago these two franchises kicked off their initial seasons. I was in the Georgia Dome that day as the Falcons defeated the Panthers 23 - 20. The Jags lost to Houston, but it was the Oilers, not the Texans. Both teams had some early success. Today, Cam Newton should have his way in Jacksonville.
Seattle 17 @ St. Louis 20: It might take a few games for the Seahawks to work Jimmy Graham into the mix. Early game for a west coast team. I'm picking the home standing Rams to pull an upset.
New Orleans 27 @ Arizona 31: I like the Saints to win the NFC South, but with a healthy Carson Palmer, the Cardinals can actually contend for a conference title.
Detroit 27 @ San Diego 28: The Chargers, in what might be their final year in San Diego, have Philip Rivers locked up long term. I think they'll show up with a lot of enthusiasm today.
Tennessee 20 @ Tampa Bay 24: This is an interesting match of the top two draft picks, Marcus Mariota and Jaemis Winston. I think Tampa has a little more weapons and Winston is better suited to the pro game.
Cincinnati 24 @ Oakland 27: The Raiders have added some players to a decimated roster and should win more than the three games they tallied last year. I look for an upset for the home team.
Baltimore 27 @ Denver 34: We'll get an early look at whether Peyton Manning's health is strong enough to carry the Broncos again. The Ravens have a lot of support to make a Super Bowl run. But the air is a lot thinner in the Rockies than it is in Baltimore.
New York Giants @ Dallas: The Cowboys are my pick to win the NFC East and I really don't care for either of these teams. They can't lose, so I'll take Dallas to open with a home win.
Philadelphia 37 @ Atlanta 27: This should be an entertaining game as Chip Kelly enters his third season with the Eagles. Can he keep the up tempo offense and still keep his defense off the field long enough to get them some rest?
Minnesota 30 @ San Francisco 24: The 'Niners had a tumultuous off-season and the Vikes have Adrian Peterson back in the lineup QB Teddy Bridgewater has made great strides.